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PhD Dissertation Writing Service - Medical Science

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My PhD thesis introduction plan:

Chapter 1: Introduction

1.1. Overview:

1.2. Malaria as a disease:

1.2.1. Malaria History

1.2.2. Malaria Pathogenesis:

1.2.3. Malaria Epidemiology:

1.2.4. Malaria Control and prevention:

1.3. Malaria parasite biology:

1.3.1. Human malaria parasite life cycle:

1.3.2. Malaria Physiology and bioenergetics process

1.3.3. Malaria sexual blood stages (gametocytes) Structure

1.3.3.1. The Biology of gaetocytogenesis

1.3.3.2. Gametocytes morphology development

1.3.3.3. Gametocytes metabolism  

1.4. Malaria Chemotherapy

1.4.1. Antimalarial drugs:

1.4.1.1.  Endoproxide Compounds

1.4.1.2.  8-Aminoquinoline

1.4.1.3.  4-aminoquinoline

1.4.1.4.  Antifolate

1.4.1.5.  Amino alcohols

1.4.1.6.  Others: eg methylene blue

1.4.2. Combination therapy of malaria treatment

1.4.2.1.  The non-Artemisinin-based combination therapy

1.4.2.2. The Artemisinin-based Combination therapy

1.5. Drug metabolism

Cytocrome p450

 

1.6. Gametocytocidal activity assays development:

1.6.1. Florescence indicator of metabolic activity

(Bolscher et al., 2015; Tanaka et al., 2013)

1.6.2. Florescence imaging

(Duffy & Avery, 2013; Lucantoni et al., 2015)

1.6.3. Chemiluminescence

(Lucantoni, Duffy, Adjalley, Fidock, & Avery, 2013; Lucantoni, Fidock, & Avery, 2016)

1.6.4. Bioluminescence assay:

(Cevenini et al., 2014; D`Alessandro et al., 2016)

Tables of summary of drug response of antimalarial on all activity assay

 

Bolscher, J. M., Koolen, K. M., van Gemert, G. J., van de Vegte-Bolmer, M. G., Bousema, T., Leroy, D., . . . Dechering, K. J. (2015). A combination of new screening assays for prioritization of transmission-blocking antimalarials reveals distinct dynamics of marketed and experimental drugs. J Antimicrob Chemother, 70(5), 1357-1366. doi:10.1093/jac/dkv003

Cevenini, L., Camarda, G., Michelini, E., Siciliano, G., Calabretta, M. M., Bona, R., . . . Alano, P. (2014). Multicolor bioluminescence boosts malaria research: quantitative dual-color assay and single-cell imaging in Plasmodium falciparum parasites. Anal Chem, 86(17), 8814-8821. doi:10.1021/ac502098w

D`Alessandro, S., Camarda, G., Corbett, Y., Siciliano, G., Parapini, S., Cevenini, L., . . . Alano, P. (2016). A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays. J Antimicrob Chemother, 71(5), 1148-1158. doi:10.1093/jac/dkv493

Duffy, S., & Avery, V. M. (2013). Identification of inhibitors of Plasmodium falciparum gametocyte development. Malar J, 12, 408. doi:10.1186/1475-2875-12-408

Lucantoni, L., Duffy, S., Adjalley, S. H., Fidock, D. A., & Avery, V. M. (2013). Identification of MMV malaria box inhibitors of plasmodium falciparum early-stage gametocytes using a luciferase-based high-throughput assay. Antimicrob Agents Chemother, 57(12), 6050-6062. doi:10.1128/AAC.00870-13

Lucantoni, L., Fidock, D. A., & Avery, V. M. (2016). Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes. Antimicrob Agents Chemother, 60(4), 2097-2107. doi:10.1128/AAC.01949-15

Lucantoni, L., Silvestrini, F., Signore, M., Siciliano, G., Eldering, M., Dechering, K. J., . . . Alano, P. (2015). A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compounds. Sci Rep, 5, 16414. doi:10.1038/srep16414

Tanaka, T. Q., Dehdashti, S. J., Nguyen, D. T., McKew, J. C., Zheng, W., & Williamson, K. C. (2013). A quantitative high throughput assay for identifying gametocytocidal compounds. Mol Biochem Parasitol, 188(1), 20-25. doi:10.1016/j.molbiopara.2013.02.005